5-Fluorouracil shell-enriched solid lipid nanoparticles (SLN) for effective skin carcinoma treatment
نویسندگان
چکیده
منابع مشابه
Solid Lipid Nanoparticles (SLN): Method, Characterization and Applications
Solid lipid nanoparticles (SLN) have emerged as a next-generation drug delivery system with potential applications in pharmaceutical field, cosmetics, research, clinical medicine and other allied sciences. Recently, increasing attention has been focused on these SLN as colloidal drug carriers for incorporating hydrophilic or lipophilic drugs. Proteins and antigens intended for therapeutic purpo...
متن کاملSolid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC): Occlusive Effect and Penetration Enhancement Ability
Objective: This work compares the occlusive effect and the penetration enhancement ability of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), through in vitro skin. Methods: SLN and NLC were prepared by high shear homogenization and characterized by size, polydispersity index, zeta potential, morphology and physical stability. Occlusive effect was assessed by an in vitr...
متن کاملEdible solid lipid nanoparticles (SLN) as carrier system for antioxidants of different lipophilicity
Ferulic acid (FA) and tocopherol (Toc) loaded solid lipid nanoparticles (SLN) were prepared by a hot homogenisation method. The particle size distribution, zeta potential and melting behaviour of the SLN as well as the stability, encapsulation efficiency and radical scavenging activity of FA and Toc in the SLN were analysed. The different formulations containing up to 2.8 mg g-1 of FA or Toc we...
متن کاملImportance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives
Solid lipid nanoparticles (SLN) have been reported to be an alternative system to emulsions, liposomes, microparticles and their polymeric counterparts for various application routes since the early 1990s due to their advantages. Various research groups have also increasingly focused on improving their stability in body fluids after administration by coating of particles with hydrophilic molecu...
متن کاملEffective treatment of advanced biliary tract carcinoma using 5-fluorouracil continuous infusion with cisplatin.
BACKGROUND The combination of 5-fluorouracil (5-FU) and cisplatin has shown great activity in many different types of tumour with an in vitro synergistic effect between 5-FU and cisplatin. A phase II study of 5-FU plus cisplatin was performed in 25 previously untreated patients with inoperable locally advanced or metastatic biliary tract carcinoma. PATIENTS AND METHODS Twenty-five patients, 1...
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ژورنال
عنوان ژورنال: Drug Delivery
سال: 2016
ISSN: 1071-7544,1521-0464
DOI: 10.1080/10717544.2016.1194498